View abstract. Int J Gynaecol Obstet 2005;91(3):221-227. View abstract. This article examines CLA’s effect on your weight and overall health. Long-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats. Recent advances in conjugated linoleic acid research. View abstract. View abstract. View abstract. Curr Opin Clin Nutr Metab Care 1999;2:499-506. View abstract. Brouwer, I. Kelley DS, Simon VA, Taylor PC, et al. 5-18-2007;356(4):1044-1049. Riserus U, Smedman A, Basu S, Vessby B. Metabolic effects of conjugated linoleic acid in humans: the Swedish experience. View abstract. Am J Clin Nutr 2002;76(4):873-882. View abstract. Vasc.Health Risk Manag. PLoS.One. De La, Torre A., Debiton, E., Durand, D., Chardigny, J. M., Berdeaux, O., Loreau, O., Barthomeuf, C., Bauchart, D., and Gruffat, D. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Int J Cancer 2-1-2006;118(3):571-576. Rigano, L., Andolfatto, C., Bonfigli, A., and Rastrelli, F. CLA Glutathione and Sodium DNA for Reducing Hair Loss. View abstract. Lambert, E. V., Goedecke, J. H., Bluett, K., Heggie, K., Claassen, A., Rae, D. E., West, S., Dugas, J., Dugas, L., Meltzeri, S., Charlton, K., and Mohede, I. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. A., Fernandez-Otero, M. P., Stanhope, K. L., Havel, P. J., and Moreno-Aliaga, M. J. Conjugated linoleic acid inhibits glucose metabolism, leptin and adiponectin secretion in primary cultured rat adipocytes. Eur J Nutr 2007;46(4):213-219. J Am Coll Nutr 2000 Apr;19:111S-8S. View abstract. Huebner, S. M., Campbell, J. P., Butz, D. E., Fulmer, T. G., Gendron-Fitzpatrick, A., and Cook, M. E. Individual isomers of conjugated linoleic acid reduce inflammation associated with established collagen-induced arthritis in DBA/1 mice. Dauchy, R. T., Dauchy, E. M., Davidson, L. K., Krause, J. O'Hagan, S. and Menzel, A. Nakamura, Y. K. and Omaye, S. T. Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. Eur J Clin Nutr 2003;57(4):595-603. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Antivir.Ther 2009;14(1):33-43. Conjugated linoleic acid is an omega-6 fatty acid. A subchronic 90-day oral rat toxicity study and in vitro genotoxicity studies with a conjugated linoleic acid product. J Bone Miner.Res 1999;14(7):1153-1162. This is a detailed review of spinach extract, a weight loss supplement that is also called Appethyl. Evans, N. P., Misyak, S. A., Schmelz, E. M., Guri, A. J., Hontecillas, R., and Bassaganya-Riera, J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. Zhao, W. S., Zhai, J. J., Wang, Y. H., Xie, P. S., Yin, X. J., Li, L. X., and Cheng, K. L. Conjugated linoleic acid supplementation enhances antihypertensive effect of ramipril in Chinese patients with obesity-related hypertension. View abstract. A., Saebo, A., Lassel, T. S., Chardigny, J. M., Sebedio, J. L., and Mensink, R. P. Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B. Atherosclerosis 2006;188(1):167-174. J Lipid Res 2008;49(1):98-106. 3-30-2007;268(1-2):50-58. View abstract. Diaz, M. L., Watkins, B. Taking conjugated linoleic acid for 12 weeks seems to improve well-being in people with birch allergies. Br J Nutr 2004;91(2):191-199. Shultz, T. D., Chew, B. P., and Seaman, W. R. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Corino, C., Pastorelli, G., Rosi, F., Bontempo, V., and Rossi, R. Effect of dietary conjugated linoleic acid supplementation in sows on performance and immunoglobulin concentration in piglets. Evidence suggests that getting small amounts of natural CLA from food is beneficial. CLA contains a mixture of different chemical forms -- or isomers -- of linoleic acid, a type of fat your body needs to function properly. Some of them are simply used for energy, while others have powerful health effects. Med Sci Sports Exerc. Mol.Cells 12-31-2008;26(6):625-630. Liu, J., Chen, B., Liu, R., and Lu, G. [Inhibitory effect of conjugated linoleic acid on human gastric carcinoma cell line]. Taking conjugated linoleic acid does not prevent or reduce symptoms of the common cold. View abstract. View abstract. View abstract. 2010;21(6):490-497. Br.J Nutr 2008;100(2):355-363. Nutr Cancer 1995;24(3):241-247. Can CLA (Conjugated Linoleic Acid) Help You Lose Weight? View abstract. Biosynthesis of conjugated linoleic acid in ruminants and humans. View abstract. Eur.J Clin Nutr 2005;59(6):742-750. J Nutr 1998;128:881-5. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Biochem.J 8-15-2007;406(1):77-83. View abstract. Quiz: What Do You Know About Vitamin B12 Deficiency? Another review gathered that CLA caused about 3 pounds (1.3 kg) more weight loss than a placebo (30). It is also a popular weight loss supplement ( 2 ). Research on the effects of conjugated linoleic acid for improving strength is mixed. Where did you or where do you plan to purchase this product? Larsen, T. M., Toubro, S., Gudmundsen, O., and Astrup, A. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. Although it doesn’t cause any serious side effects at doses up to 6 grams per day, concerns exist about the long-term health effects of supplemental doses. Conjugated linoleic acid is used for cancer, “hardening of the arteries” (atherosclerosis), obesity, weight loss caused by chronic disease, bodybuilding, and limiting food allergy reactions. A., Wu, H. C., Farquharson, A., Grant, I., Arthur, J. R., Rotondo, D., Choe, S. N., and Wahle, K. W. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. View abstract. Eur J Nutr 2012;51(2):127-34.View abstract. Sluijs, I., Plantinga, Y., de Roos, B., Mennen, L. I., and Bots, M. L. Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. This is due to its effect on molecular pathways that regulate fat burning. View abstract. McClelland, S., Cox, C., O'Connor, R., de Gaetano, M., McCarthy, C., Cryan, L., Fitzgerald, D., and Belton, O. Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte/macrophage cell. MacRedmond, R., Singhera, G., Attridge, S., Bahzad, M., Fava, C., Lai, Y., Hallstrand, T. S., and Dorscheid, D. R. Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics. Of course, grass-fed beef and dairy products are healthy for various other reasons. Arterioscler.Thromb.Vasc.Biol 2006;26(2):307-312. Numerous studies show that industrial trans fats — which are different from natural trans fats like CLA — are harmful when consumed in high amounts (5, 6, 7). Biosci.Biotechnol.Biochem. Dairy foods and meat contain conjugated linoleic acid (CLA) 1 2 3. View abstract. But does CLA safflower oil actually help you lose weight? A., Liu, L. F., and Belury, M. A. Conjugated linoleic acid does not reduce body fat but decreases hepatic steatosis in adult Wistar rats. Yun, H. S., Do, S. H., Jeong, W. I., Yang, H. J., Yuan, D. W., Hong, I. H., Lee, H. R., Lee, I. S., Kim, Y. K., Choi, M. S., Kim, H. A., and Jeong, K. S. Cytotoxic effects of the conjugated linoleic acid isomers t10c12, c9t11-CLA and mixed form on rat hepatic stellate cells and CCl4-induced hepatic fibrosis. Byeon, J. I., Song, H. S., Oh, T. W., Kim, Y. S., Choi, B. D., Kim, H. C., Kim, J. O., Shim, K. H., and Ha, Y. L. Growth inhibition of foodborne and pathogenic bacteria by conjugated linoleic acid. View abstract. View abstract. Am J Clin Nutr 2004;79:1118-25. View abstract. Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans. J Nutr 2009;139(7):1347-1352. Revista Espanola de Obesidad 2007;5(2):109-118. Prostaglandins Leukot.Essent.Fatty Acids 2010;82(2-3):105-109. 3-13-2000;150(1):93-100. Acute oral safety study of dairy fat rich in trans-10 C18:1 versus vaccenic plus conjugated linoleic acid in rats. Anticancer Res 2005;25(6B):3943-3949. Several animal studies have observed harmful side effects from CLA, such as increased liver fat. Anticancer Res 2003;23(6C):4765-4772. Am J Physiol 1998;275:R667-72. Kim, E. J., Kang, I. J., Cho, H. J., Kim, W. K., Ha, Y. L., and Park, J. H. Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. J Oleo.Sci 2007;56(10):517-525. Conjugated Linoleic acid supplements are generally available in solid capsule or liquid form. Lin, Y., Schuurbiers, E., Van, der, V, and de Deckere, E. A. Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. Iranian Journal of Endocrinology & Metabolism 2010;12(1):84. Their two double bonds are conjugated (i.e., separated by a single bond). Ens JG, Ma DW, Cole KS, et al. J Nutr 2003;133(2):456-460. Br J Nutr 2002;88(6):625-634. Nagao, K., Inoue, N., Wang, Y. M., Shirouchi, B., and Yanagita, T. Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. Although found in whole foods, consuming enough of these foods to get enough CLA would be detrimental to your health, and expensive to boot, which is why CLA supplements are now more popular than ever before. Lipids 2001;36:669-74. A., Barker, P. A., Bestwick, C., Choe, S. N., McClinton, S., Grant, I., Rotondo, D., Heys, S. D., and Wahle, K. W. Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells. Br Poult.Sci 2003;44(2):203-210. de Veth, M. J., Bauman, D. E., Koch, W., Mann, G. E., Pfeiffer, A. M., and Butler, W. R. Efficacy of conjugated linoleic acid for improving reproduction: a multi-study analysis in early-lactation dairy cows. J Nutr 2010;140(3):515-521. 2007;18(7):467-474. Author information: (1)Providence Healthcare Heart + Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. Cornish, S. M., Candow, D. G., Jantz, N. T., Chilibeck, P. D., Little, J. P., Forbes, S., Abeysekara, S., and Zello, G. A. Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training. Diabetes Res Clin.Pract. In Vitro Cell Dev Biol Anim 2003;39(8-9):375-382. View abstract. The “conjugated” prefix has to do with the arrangement of the double bonds in the fatty acid molecule. While these weight loss effects may be statistically significant, they are small — and there is potential for side effects. Taking conjugated linoleic acid for 12 weeks seems to improve airway sensitivity and ability to exercise in people with asthma. View abstract. Weiler, H. A., Fitzpatrick, S., and Fitzpatrick-Wong, S. C. Dietary conjugated linoleic acid in the cis-9, trans-11 isoform reduces parathyroid hormone in male, but not female, rats. Sebedio JL, Gnaedig S, Chardigny JM. Obesity. Am J Physiol Gastrointest.Liver Physiol 2002;283(2):G357-G367. Shultz, T. D., Chew, B. P., Seaman, W. R., and Luedecke, L. O. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells. View abstract. Wang, L. S., Huang, Y. W., Sugimoto, Y., Liu, S., Chang, H. L., Ye, W., Shu, S., and Lin, Y. C. Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells. Nortadas R, Barata J. Fulminant hepatitis during self-medication with conjugated linoleic acid. J Med Food 2010;13(1):13-19. Does CLA work for weight loss? Zhao, L., Yin, J., Li, D., Lai, C., Chen, X., and Ma, D. Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. View abstract. Most studies on CLA have used doses of 3.2–6.4 grams per day. However, bear in mind that the risk of side effects increases as your dosage increases. Zhou, X. R., Sun, C. H., Liu, J. R., and Zhao, D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Uncontrolled Blood Sugar: How Dangerous Is It? J Biochem.Mol.Biol 9-30-2002;35(5):494-497. (1) Among the most popular weight loss supplements used worldwide, CLA may also reduce the risk of developing type 2 diabetes and cancer. Wanders, A. J., Brouwer, I. Anticancer Res 2006;26(1A):27-34. 2-18-2000;468(1):33-36. View abstract. View abstract. View abstract. Shadman, Z., Rastmanesh, R., Hedayati, M., Taleban, F. A., Saadat, N., Tahbaz, F., and Mehrabi, Y. View abstract. Am.J Clin.Nutr 2009;90(3):468-476. View abstract. Stachowska, E., Baskiewicz-Masiuk, M., Dziedziejko, V., Gutowska, I., Baranowska-Bosiacka, I., Marchlewicz, M., Dolegowska, B., Wiszniewska, B., Machalinski, B., and Chlubek, D. Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. View abstract. Many long-term observational studies have assessed disease risk in people who consume larger amounts of CLA. View abstract. View abstract. Conjugated linoleic acid and the control of cancer and obesity. Some people may experience mild to moderate side effects, including stomach upset, diarrhea, and nausea.15 Conjugated linoleic acid may also slow blood clotting. The FDA allows CLA to be added to foods and gives it a GRAS (generally regarded as safe) status. 2004;44(1):59-67. Petridou, A., Mougios, V., and Sagredos, A. Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. J Med Food 2006;9(1):22-27. Circulation 10-8-2002;106(15):1925-1929. (Lond) 2007;31(7):1148-1154. Br.J Nutr 2007;97(5):1001-1011. Stringer, D. M., Zahradka, P., Declercq, V. C., Ryz, N. R., Diakiw, R., Burr, L. L., Xie, X., and Taylor, C. G. Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Exp.Biol.Med (Maywood.) Zambell, K. L., Keim, N. L., Van Loan, M. D., Gale, B., Benito, P., Kelley, D. S., and Nelson, G. J. Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Hunt, W. T., Kamboj, A., Anderson, H. D., and Anderson, C. M. Protection of cortical neurons from excitotoxicity by conjugated linoleic acid. CLA has been shown to have many biological effects, including anticarcinogenisis, antiatherogenesis, immune modulation, and changes in body composition, and is commercially available as an over-the-counter sup… Eur.J Med Res 8-20-2003;8(8):370-372. A., Lynch, D. T., Tirrell, P. C., Tirrell, R. P., Sauer, L. A., Van der, Riet P., and Blask, D. E. Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids. Choi, J. S., Jung, M. H., Park, H. S., and Song, J. Yurawecz, M. P., Roach, J. It may also improve body composition by reducing body fat and increasing muscle mass (21, 22, 23, 24, 25). J Nutr 2010;140(8):1454-1461. View abstract. Studies suggest that CLA has only modest effects on weight loss. This article explains if CLA can help you lose weight. Can the CLA in Safflower Oil Help You Lose Weight? Lipids 2000;35(7):777-782. Supplementation of conjugated linoleic acid (CLA) tends to be in the range of 3,200-6,400mg daily, taken with meals. View abstract. J Agric.Food Chem. Sakono, M., Miyanaga, F., Kawahara, S., Yamauchi, K., Fukuda, N., Watanabe, K., Iwata, T., and Sugano, M. Dietary conjugated linoleic acid reciprocally modifies ketogenesis and lipid secretion by the rat liver. J Lipid Res 2009;50(3):467-476. Oikawa, D., Nakanishi, T., Nakamura, Y., Takahashi, Y., Yamamoto, T., Shiba, N., Tobisa, M., Takagi, T., Iwamoto, H., Tachibana, T., and Furuse, M. Dietary CLA and DHA modify skin properties in mice. View abstract. Conjugated linoleic acid (CLA) is a fatty acid found in meat and dairy that is believed to have various health benefits . Pinkoski, C., Chilibeck, P. D., Candow, D. G., Esliger, D., Ewaschuk, J. View abstract. View abstract. Kamphuis, M. M., Lejeune, M. P., Saris, W. H., and Westerterp-Plantenga, M. S. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Lenz, T. L. and Hamilton, W. R. Supplemental products used for weight loss. Park, H. S., Chun, C. S., Kim, S., Ha, Y. L., and Park, J. H. Dietary trans-10, cis-12 and cis-9,trans-11 Conjugated Linoleic Acids Induce Apoptosis in the Colonic Mucosa of Rats Treated with 1,2-Dimethylhydrazine. Cao, Z. P., Wang, F., Xiang, X. S., Cao, R., Zhang, W. B., and Gao, S. B. Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP. Lipids Health Dis. View abstract. Kreider, R. B., Ferreira, M. P., Greenwood, M., Wilson, M., and Almada, A. L. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. In nature, CLA is mostly found in the fatty meat and dairy of ruminant animals. J Agric.Food Chem 9-7-2005;53(18):7295-7301. View abstract. Arch Anim Nutr 2005;59(6):429-438. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Epub 2020 Jun 8. Perseghin, G., Caumo, A., Caloni, M., Testolin, G., and Luzi, L. Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. Adv Food Nutr Res 2005;50:179-217.View abstract. 1999;28(6):353-355. View abstract. J Nutr Biochem 2001;12:585-94.. View abstract. View abstract. View abstract. It’s one of the magic ingredients that make grass-fed butter and meat so incredible for boosting your physical performance. View abstract. View abstract. Thrush, A. Athletic performance. pii: E1730. In colorectal cancer cells in humans, CLA supplements have been seen to improve growth arrest by blocking the production of energy in cancer cells. 12 Over-The-Counter Appetite Suppressants Reviewed, Omega-3-6-9 Fatty Acids: A Complete Overview, 12 Popular Weight Loss Pills and Supplements Reviewed. People more often refer to it as CLA and use CLA supplements for weight loss, bodybuilding, and diabetes. Mol.Cell Endocrinol. 1999;63(6):1104-1106. View abstract. Castaneda-Gutierrez, E., Benefield, B. C., de Veth, M. J., Santos, N. R., Gilbert, R. O., Butler, W. R., and Bauman, D. E. Evaluation of the mechanism of action of conjugated linoleic acid isomers on reproduction in dairy cows. Nutr Res 2001;21:955-60. Am.J Hypertens. View abstract. Roy, B. D., Bourgeois, J., Rodriguez, C., Payne, E., Young, K., Shaughnessy, S. G., and Tarnopolosky, M. A. Conjugated linoleic acid prevents growth attenuation induced by corticosteroid administration and increases bone mineral content in young rats. Steinhart, H., Rickert, R., and Winkler, K. Identification and analysis of conjugated linoleic acid isomers (CLA). Takahashi, Y., Kushiro, M., Shinohara, K., and Ide, T. Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. View abstract. View abstract. Lipids 2014;49(9):871-80. Brownbill, R. A., Petrosian, M., and Ilich, J. It is a common ingredient in weight loss supplements either on its own or coupled with other ingredients. Hay fever. 2008;82(3):e23-e24. Fischer-Posovszky, P., Kukulus, V., Zulet, M. A., Debatin, K. M., and Wabitsch, M. Conjugated linoleic acids promote human fat cell apoptosis. Kloss, R., Linscheid, J., Johnson, A., Lawson, B., Edwards, K., Linder, T., Stocker, K., Petitte, J., and Kern, M. Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat. 2020 Sep 24;30(10):1777-1784. doi: 10.1016/j.numecd.2020.05.029. Chao, P. M., Chen, W. H., Liao, C. H., and Shaw, H. M. Conjugated linoleic acid causes a marked increase in liver alpha-tocopherol and liver alpha-tocopherol transfer protein in C57BL/6 J mice. Malpuech-Brugere, C., Verboeket-van de Venne WP, Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Saebo, A., Lassel, T. S., Chardigny, J. M., Sebedio, J. L., and Beaufrere, B. They are usually of a different form than the CLA found naturally in foods. View abstract. J Am Pharm Assoc (Wash.DC.) 2010;48(2):591-598. Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. Jaudszus, A., Krokowski, M., Mockel, P., Darcan, Y., Avagyan, A., Matricardi, P., Jahreis, G., and Hamelmann, E. Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARgamma-related mechanism in mice. Cancer Lett 4-15-1992;63(2):125-133. This article explains what these fats are and how to get…. Whigham, L. D., Watras, A. C., and Schoeller, D. A. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Bonet, S. B., Quintanar, R. A., Viana, A. M., Iglesias-Gutierrez, E., and Varela-Moreiras, G. The effects of yogurt with isomer enriched conjugated linoleic acid on insulin resistance in obese adolescents. A., Carne, X., Vidal, S., Mas, S., Deulofeu, R., and Lafuente, A. Lipids 1997;32(8):853-858. Int J Cancer 12-20-2005;117(6):923-933. Larsen, T. M., Toubro, S., and Astrup, A. Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. Palmquist DL, Lock AL, Shingfield KJ, Bauman DE. The effects are most pronounced during the first six months, after which fat loss plateaus for up to two years. Syvertsen, C., Halse, J., Hoivik, H. O., Gaullier, J. M., Nurminiemi, M., Kristiansen, K., Einerhand, A., O'Shea, M., and Gudmundsen, O. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Numerous studies in both animals and humans reveal that CLA can drive inflammation, cause insulin resistance and lower “good” HDL cholesterol (38, 39). Conjugated linoleic acid and disease prevention: a review of current knowledge. Supplemental doses are also much higher than the amounts people get from dairy or meat. View abstract. J Nutr Biochem. View abstract. J Med Food 2003;6(3):193-199. Sneddon, A. Toxicol Sci 1999;52:107-10. Riserus U, Vessby B, Arner P, Zethelius B. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. View abstract. Ramos, R., Mascarenhas, J., Duarte, P., Vicente, C., and Casteleiro, C. Conjugated linoleic acid-induced toxic hepatitis: first case report. View abstract. View abstract. Park, N. Y., Valacchi, G., and Lim, Y. Biochem.Biophys.Res Commun. View abstract. View abstract. View abstract. Am.J Clin.Nutr 2010;91(1):175-183. Lipids 1998;33(8):803-809. (Lond) 2007;31(3):481-487. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S., and Ezaki, O. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Gaullier JM, Halse J, Hoye K, et al. View abstract. View abstract. Lipids 2001;36(3):229-236. View abstract. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. PLoS.One. View abstract. A new conjugated linoleic acid isomer, 7 trans, 9 cis-octadecadienoic acid, in cow milk, cheese, beef and human milk and adipose tissue. Med Sci Sports Exerc. Carcinogenesis 2006;27(5):972-981. 8-4-2010; View abstract. A. Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. Croat Med J 2016;57(4):331-42. FEBS Lett. Ip, M. M., Masso-Welch, P. A., Shoemaker, S. F., Shea-Eaton, W. K., and Ip, C. Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Risks. Appl.Physiol Nutr Metab 2007;32(3):372-382. Large doses of supplemental CLA can cause increased accumulation of fat in your liver, which is a stepping stone towards metabolic syndrome and diabetes (35, 36, 37). Lipids 2003;38(6):609-614. Paek, J., Kang, J. H., Kim, S. S., Son, K. A., Park, M. R., and Yang, M. P. Trans-10, cis-12 conjugated linoleic acid directly enhances the chemotactic activity of porcine peripheral blood polymorphonuclear neutrophillic leukocytes by activating F-actin polymerization in vitro. J Agric.Food Chem 10-9-2002;50(21):6188-6193. Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans. Anticancer Res 1999;19:1953-60. Herrmann, J., Rubin, D., Hasler, R., Helwig, U., Pfeuffer, M., Auinger, A., Laue, C., Winkler, P., Schreiber, S., Bell, D., and Schrezenmeir, J. Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study. Matin S, Nemati A, Ghobadi H, Alipanah-Moghadam R, Rezagholizadeh L. The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD. The main dietary sources of CLA are dairy and meat from cows, goats and sheep, whereas CLA supplements are made by chemically altering vegetable oils. J Nutr 2003;133(3):663-667. View abstract. 2009;8:22. While it is technically a trans fat, it’s very different from the industrial trans fats that harm your health. Growth Horm.IGF.Res 2008;18(5):361-368. Taking a CLA supplement along with an anticoagulant ("blood thinners") or nonsteroidal anti-inflammatory drug (NSAID) can further enhance this effecting, leading to easy bruising and bleeding.14 Possible drug interactions include: 1. CLA helps your body build muscle rather than store fat and has anti-inflammatory properties. Wendel, A. Keep in mind that the CLA you find in supplements is not derived from natural foods but made by chemically altering linoleic acid found in vegetable oils (11). Biochem.Biophys.Res Commun. Kim, J. H., Hubbard, N. E., Ziboh, V., and Erickson, K. L. Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. View abstract. The effects of conjugated linoleic acid supplementation during resistance training. In fact, CLA may be one of the most comprehensively studied weight loss supplement in the world. Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E. The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. A., and Thompson, H. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. 4-13-2009; View abstract. Matsuda, M. and DeFronzo, R. A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Song, H. J., Sneddon, A. Chung, S., Brown, J. M., Sandberg, M. B., and McIntosh, M. Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. Hubbard, N. E., Lim, D., Summers, L., and Erickson, K. L. Reduction of murine mammary tumor metastasis by conjugated linoleic acid. Pariza, M. W., Park, Y., and Cook, M. E. The biologically active isomers of conjugated linoleic acid. Lipids 2001;36(3):221-227. Tsuzuki, T. and Ikeda, I. Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans--a quantitative review. Identification of conjugated linoleic acids in hydrogenated soybean oil by silver ion-impregnated HPLC and gas chromatography-ion impacted mass spectrometry of their 4,4-dimethyloxazoline derivatives. View abstract. View abstract. J Neurochem. Roman, J. L., Gonzalvez, A. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. View abstract. Ostrowska, E., Cross, R. F., Muralitharan, M., Bauman, D. E., and Dunshea, F. R. Effects of dietary fat and conjugated linoleic acid on plasma metabolite concentrations and metabolic responses to homeostatic signals in pigs. In animal studies it has been shown to have numerous benefits including decreased body fat, increased muscle mass and enhanced immunity. Drury, B., Warford-Woolgar, L. J., Herchak, D. J., Bankovic-Calic, N., Crow, G., Taylor, C. G., Zahradka, P., Ogborn, M. R., and Aukema, H. M. Dietary trans-10, cis-12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa zucker rats. Effects of rumenic acid rich conjugated linoleic acid supplementation on cognitive function and handgrip performance in older men and women. View abstract. View abstract. View abstract. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. J Am Coll Nutr 2005;24(3):177-181. 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